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Evaluate the immunogenic potential of senescent cells through their display of unique MHC I-associated peptides - Jobs in Montréal, QC

Job LocationMontréal, QC
EducationNot Mentioned
SalaryNot Disclosed
IndustryNot Mentioned
Functional AreaNot Mentioned
Job TypeFull Time

Job Description

Evaluate the immunogenic potential of senescent cells through their display of unique MHC I-associated peptidesRéf ABG-108628 Sujet de Thèse31/10/2022 Financement public/privéChristian BeausejourLieu de travailmontreal - CanadaIntitulé du sujetEvaluate the immunogenic potential of senescent cells through their display of unique MHC I-associated peptidesChamps scientifiques

  • Biologie
Description du sujetFor this project, 155 peptides specific to senescent human fibroblasts were identified using an unbiased immunopeptidomic screen. The hypothesis is that some of these peptides could be used to activate the immune system. The main objectives will be to perform immune-based experiments to determine if these peptides can lead to the immune rejection of deleterious senescent cells. It is also expected to identify specific markers for the identification of senescent cells in vivo. This project combines molecular and cell biology in the field of cancer and immunology. The candidate will benefit from the complementary expertise of a multidisciplinary team and of a rich research environment.Prise de fonction :30/11/2022Nature du financementFinancement public/privéPrécisions sur le financementCIHRPrésentation établissement et labo daccueilChristian BeausejourThe project will be conducted in the multidisciplinary environment of the CHU Sainte-Justine Research Center and the applicants would be affiliated to Université de Montréal. The laboratory of Dr Beauséjour is looking to decipher the role of senescence in immunosuppression and resistance to cancer treatments. As the scientific director of the cell reprogramming platform, Dr Beauséjour uses induced pluripotent stem cells as tools to develop novel cell therapy approaches.Intitulé du doctoratDoctorat en pharmacologie et physiologiePays dobtention du doctoratCanadaEtablissement délivrant le doctoratUniveristé de MontréalRequired/preferred training and profile  Demonstrate motivation and autonomy to bring this project to term;  Possess a strong knowledge in immunology and cellular biology (eg. Flow cytometry);  Have experience with cell culture.  Have good communication and organization skills.  Although University of Montreal and the CHU Sainte-Justine are french-speaking institution, it is not required that the candidate speaks and/or understand French at the postdoctoral level.Profil du candidatRequired/preferred training and profile
  • Demonstrate motivation and autonomy to bring this project to term;
  • Possess a strong knowledge in immunology and cellular biology (eg. Flow cytometry);
  • Have experience with cell culture.
  • Have good communication and organization skills.
  • team player
Date limite de candidature30/11/2022Quick Apply
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