Post-doctoral Position: Investigating the molecular mechanisms underlying cellular senescence in retinopathy - Jobs in Montréal, QC

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Post-doctoral Position: Investigating the molecular mechanisms underlying cellular senescence in retinopathyRéf ABG-108801 Sujet de Thèse09/11/2022 Financement public/privéUniversité de Montréal / Centre de recherche Hôpital Maisonneuve-RosemontLieu de travailMontréal - CanadaIntitulé du sujetPost-doctoral Position: Investigating the molecular mechanisms underlying cellular senescence in retinopathyChamps scientifiques

• Biochimie
• Biologie

Mots clésInflammation, cellular senescence, epigenetics, metabolism, immune cell, retinopathy, angiogenesis.Description du sujetPost-doctoral Position: Investigating the molecular mechanisms underlying cellular senescence in retinopathyIschemic retinopathies such as retinopathy of prematurity (ROP) and diabetic retinopathy (DR) affect close to 10 million North Americans and are leading causes of blindness in developed countries. The breakdown of vascular beds in these ischemic conditions prevents nutrient and oxygen delivery and leads to hypoxic/ischemic events and a constellation of biochemical changes that compromise cellular function. Neurons that are the most closely associated with degenerated vasculature such as retinal ganglion cells in ischemic retinopathies only modestly trigger apoptosis despite a severely compromised metabolic supply but rather enter a state of cellular senescence, a stress response in which the cells remains viable but with altered and compromised function. Senescent cells secrete numerous inflammatory cytokines, a phenomenon called the senescence-associated secretory phenotype (SASP), which alters the tissue microenvironment and promotes senescence in surrounding cells, and also contributes to the recruitment of immune cells. We recently demonstrated that limiting the SASP displays beneficial effects on reparative vascular regeneration upon ischemic stress. However, the molecular mechanisms underlying regulation of the SASP under such conditions remain to be elucidated. Our previous research demonstrated the critical role of the inflammatory response mediated by senescent cells in retinopathy (Oubaha et al. Science Translational Medicine 2016), as well ass the immune clearance of senescent cells (Binet et al. Science 2020). The proposed research will focus on the identification of the molecular mechanisms involved in the regulation of the inflammatory response of senescent cells.Our group is studying the molecular mechanisms underlying the interplay between the chromatin structure and cell transformation and aging. We use state-of-the-art technologies in biochemistry, molecular biology, genetics, epigenetics and metabolomics to investigate oncogene cooperation. Projects in our group are linking epigenetics with telomere biology, oncogenes, cellular senescence and metabolism (Binet et al. Science 2020; Carbonneau et al. Nature Communications 2016; Oubaha et al. Science Translational Medicine 2016; Neault et al. Cell Reports 2016; Jin et al. Immunity 2014; Deschênes-Simard et al. Genes&Dev 2013; Mallette et al. EMBO J. 2012; Mallette et al. Cell Reports 2012; Neault et al. NAR 2012; Mallette et al. Genes&Dev 2007).Nature du financementFinancement public/privéPrécisions sur le financementThe annual fellowship allocated to post-PhD starts around 40,000$ at Maisonneuve-Rosemont Research Center. Furthermore, competitive fellowships are also available (40-50k$) to post-doc with exceptional track record.Présentation établissement et labo daccueilUniversité de Montréal / Centre de recherche Hôpital Maisonneuve-RosemontThe Chromatin Structure and Cellular Senescence research unit at the Maisonneuve-Rosemont Hospital Research Center is actively recruiting talented and highly motivated candidates for PhD. The candidate will work in a recently build research center and will be affiliated to the Biochemistry department of the University of Montreal. The candidate will use biochemical, genomics, proteomics, metabolomics, cytological and genetic approaches to study the molecular mechanisms of cancer.Affiliated to the University of Montreal, the Maisonneuve-Rosemont Hospital Research Center represents a leading institution integrating fundamental, translational and clinical researchs.The Chromatin Structure and Cellular Senescence research unit is localized in a new building equipped with state-of-the-art equipements and privileged access to core facilities and technological platforms such as mouse facility, histology, proteomics, metabolomics and genomics. In addition, the research center is offering bonified PhD studentship to candidates with exceptional track record.Site web :https://crhmr.ciusss-estmtl.gouv.qc.ca/fr/chercheur/frederick-antoine-malletteIntitulé du doctoratPost-doctoral fellowship in BiochemistryPays dobtention du doctoratCanadaEtablissement délivrant le doctoratUniversité de MontréalProfil du candidatCandidates should display solid expertise in molecular biology, biochemistry and/or cell biology. A PhD (to be completed soon or obtained within the last year) in Biochemistry, Molecular biology or other related biological sciences is a pre-requisite. Candidates should be dynamic, hard-worker, have a solid work ethic and strong academic grades. Publications in top-tier journals is a pre-requisite. Candidates should send by email their CV, university transcripts, a list of 3 referees and a cover letter describing their research experience and career objectives.Date limite de candidature31/01/2023Quick Apply

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