Research Assistant, Process Development - Jobs in Vancouver, BC

Job Description

Acuitas Therapeutics is a private biotechnology company based in Vancouver, British Columbia, Canada. We are the premier global provider of LNP delivery systems for nucleic acid therapeutics. Acuitas is partnered with multiple international, biotechnology and pharmaceutical partners who are focused on bringing new vaccines and drugs into clinical development and to the marketplace.At Acuitas Therapeutics we believe in combining excellent science with an enviable work culture. The advanced LNP technologies we provide for our partners are made possible by our employees who apply their passion, curiosity, and knowledge every step of the way. At Acuitas you will have the opportunity to work as part of a close-knit team of exceptional scientists, who support the production of revolutionary technology that impacts the health and wellness of society. By living our values, including honesty, integrity, innovation and openness we have fostered a supportive work environment where our employees feel empowered, challenged, recognized and rewarded. If you would like to work for a company that is at the top of the field Acuitas is the company for you! All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law.Position: Research Assistant, Process DevelopmentAcuitas Therapeutics is seeking a Research Assistant to work in the Process Development group reporting to the Director, Chemistry, Manufacturing and Controls (CMC). The Research Assistant will be responsible for design and execution of studies, including development and characterization of manufacturing processes for lipid nanoparticle systems, supporting the transfer of manufacturing processes to third-party sites (CMOs), managing and executing analyses, as well as interpreting and presenting results.Responsibilities:The Research Assistant will perform research related to the development of RNA LNP formulations for in vivo and in vitro applications, characterization of biophysical attributes, contribute to the understanding of the biological mechanisms of action and to optimization of formulation processes at various scales.Working under the direction of the Director, CMC, the responsibilities would encompass aspects shown below.

• Development, optimization and troubleshooting of formulations and manufacturing processes at various scales.
• Participation in technology transfer activities related to manufacturing processes and/or analytical methods to ensure progress and success of external partner programs.
• Characterization of LNP formulations and components using standard in-house assays and development of new assays or detailed investigations of specific LNP attributes as required.
• Collaborate with other departments including Formulation Development and Analytical to analyze and interpret data.
• Maintain accurate laboratory notes and data files as well as regularly prepare internal reports of their work.
• Laboratory management duties related to operations and maintenance of the Process Development Functions.
• Maintain familiarity with relevant scientific knowledge and advancements.

Requirements:

• A minimum level of education, training, and experience equivalent to a Bachelor of Science or MSc in an appropriate discipline with two (2) years of recent related experience in a research laboratory.
• The successful candidate will have excellent bench skills, the ability to develop and master new techniques quickly, and be able to work independently.
• Preferred candidates will have experience working with lipid nanoparticle formulations including production and/or characterization of LNP formulations by standard and/or specialized analytical techniques (e.g. absorption and fluorescence spectrometry, chromatographic separations, etc).
• Familiarity with statistical design of experiments, data modeling, tangential flow filtration, scale up process development, GMP experience and/or regulatory aspects of LNP products and raw materials would be an asset.

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